Basic Science Research

Biomarker Discovery Center
Established at the NJISA in late 2012, the Biomarker Discovery Center builds on the recent discoveries by NJISA researchers that could significantly change the diagnosis and treatment of a number of diseases. The Center is under the direction of Robert Nagele, PhD, who has received national recognition for his published research into the use of blood-borne biomarkers to diagnose early stages of Alzheimer’s and Parkinson’s diseases.

Scientific and medical interest in biomarkers has intensified in recent years. The need for early diagnostics that are accurate, relatively non-invasive and cost effective is critical and Dr. Nagele’s published research has illustrated some promising early results, including:

In January 2013, the Biomarker Discovery Center was awarded a three-year, $799,800 grant from the Osteopathic Heritage Foundation to develop a blood test that can diagnose mild cognitive impairment caused by early-stage Alzheimer’s disease.

Along with Alzheimer’s and Parkinson’s diseases, ongoing projects at the Biomarker Discovery Center are focusing on blood-based biomarkers for the early detection of multiple sclerosis and various types of cancer and the potential use of these biomarkers to measure the ability of medications to treat these diseases.

Recent Publications by Robert Nagele, PhD
Acharya, NK, EC Levin, PM Clifford, M Han, R Tourtellotte, D Chamberlain, M Pollaro, N Coretti, MC Kosciuk, EP Nagele, C DeMarshall, T Freeman, Y Shi, C Guan, CH Macphee, RL Wilensky, and RG Nagele. (2013), Diabetes and hypercholesterolemia increase blood brain barrier permeability and brain amyloid deposition: beneficial effects of the LpPLA2 inhibitor darapladib. Journal of Alzheimer’s Disease, 35:179-198.

Nagele EP, Han M, Acharya NK, DeMarshall C, Kosciuk MC, Nagele RG. (2013) Natural IgG autoantibodies are abundant and ubiquitous in human sera, and their number is influenced by age, gender, and disease. PLoS One, 8(4):e60726. doi:10.1371/journal.pone.0060726.
103. Acharya NK, Nagele EP, Han M, and Nagele RG. (2013) Autoantibodies: Double Agents in Human Disease. Science Translational Medicine, 5, 186fs19.

Ochoa-Alvarez JA, Krishnan H, Shen Y, Acharya NK, Han M, McNulty DE, Hasegawa H, Hyodo T, Senga T, Geng JG, Kosciuk M, Shin SS, Goydos JS, Temiakov D, Nagele RG, Goldberg GS. (2013) Plant lectin can target receptors containing sialic Acid, exemplified by podoplanin, to inhibit transformed cell growth and migration. PLoS One. 7(7):e41845. Epub 2012 Jul 23.

Chu H-P, Y Liao, JS Novak, Z Hu, JJ Merkin, Y Shymkiv, BP Braeckman, MV Dorovkov, A Nguyen, PM Clifford, RG Nagele, DE Harrison and RE Ellis. (2014) Germline quality control: eEF2K stands guard to eliminate defective oocytes. Dev. Cell 28:561-572.

Acharya NK, Goldwaser EL, Forsberg MM, Godsey GA, Johnson CA, Sarkar A, DeMarshall C, Kosciuk MC, Dash JM, Hale CP, Leonard D, Appelt DM, and Nagele RG. (2015) Sevoflurane and Isoflurane induce structural changes in brain vascular endothelial cells and increase blood-brain barrier permeability: Possible link to postoperative delirium and cognitive decline. Brain Research, Brain Res 2015 May 8. Epub 2015 May 8.

DeMarshall C, Abhirup Sarkar, Eric P. Nagele, Eric Goldwaser, George Godsey, Nimish K. Acharya and Robert G. Nagele (2015) Utility of Autoantibodies as Biomarkers for Diagnosis and Staging of Neurodegenerative Diseases. Int. Rev Neurobiol., in press. (Invited Review).